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Updated: May 20, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
[Blood lactic acid level and APACHE II score on prognosis of critically ill elderly patients]
Bin Bao1, Zhi-gang Li, Xiao-lin Sun
1Department of Emergency, Tianjin the Forth Central Hospital, Tianjin 300140, China. baobin1101@sina.com
Objective:
To analyze the relevance between blood lactic acid level and acute physiology and chronic health evaluation II (APACHE II) score in order to provide guideline for clinical treatment.
Methods:
Retrospective analyses on 537 critically ill elderly patients who were hospitalized in the ICU with their blood lactic acid level tested and APACHE II scores calculated.
Results:
The overall death rate was 35.75% (192/537) with the APACHE II score as (22.6±12.8), and blood lactic acid level as (6.84±2.01) mmol/L. The blood lactic acid level among deaths was obviously higher than in the control group, with significant differences (P<0.05). The level of blood lactic acid was positively related to APACHE II score (r=0.572, P<0.05) while the death rate was both positively related to APACHE II score (r=0.475, P<0.05) and the level of blood lactic acid (r=0.506, P<0.05).
Conclusion:
There seemed a positive correlation between blood lactic acid level and the APACHE II score. Both of them showed good relevance with the prognosis of the disease.
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