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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
IP(3) receptors, stress and apoptosis
Lubomira Lencesova1, Olga Krizanova
1Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Bratislava, Slovak Republic.
General Physiology and Biophysics
|July 12, 2012
Summary
Inositol 1,4,5-trisphosphate (IP3) receptors, crucial calcium channels, are modulated by stress and apoptosis. Understanding these interactions may lead to new therapeutic strategies targeting IP3 receptor function.
Area of Science:
- Cellular Biology
- Molecular Pharmacology
Background:
- Inositol 1,4,5-trisphosphate (IP3) receptors are key intracellular calcium channels.
- They regulate calcium release and are implicated in physiological and pathophysiological processes.
Purpose of the Study:
- To review the modulation of IP3 receptors by various stressors.
- To focus on the impact of hypoxic stress and apoptosis on IP3 receptor expression and function.
Main Methods:
- Literature review of studies on IP3 receptor modulation by stress factors.
- Analysis of the relationship between hypoxia, apoptosis, and IP3 receptor expression.
Main Results:
- Stress factors like immobilization, oxidative stress, and hypoxia can alter IP3 receptor expression.
- Hypoxia, particularly strong or prolonged, may induce apoptosis, affecting IP3 receptor function.
Conclusions:
- Modulation of IP3 receptors by stressors is significant.
- Further research into hypoxic stress and apoptosis offers potential for novel therapeutic interventions targeting IP3 receptors.
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