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[Hemostasis in patients with systemic skin diseases]
Vestnik Dermatologii I Venerologii
|January 1, 1990
Summary
Patients with scleroderma, psoriatic arthritis, and skin lymphoma show impaired blood clotting (hemostasis). Disease severity correlates with the extent of clotting abnormalities, impacting skin and joint health.
Area of Science:
- Hematology
- Dermatology
- Rheumatology
Context:
- Investigating hemostasis system parameters in patients diagnosed with specific dermatological and rheumatological conditions.
- Focusing on scleroderma, psoriatic arthritis, and malignant lymphoma of the skin.
Purpose:
- To analyze alterations in coagulation parameters within these patient groups.
- To establish correlations between disease severity and hemostasis system dysfunction.
Summary:
- Significant elevations in fibrinogen concentration and accelerated blood clotting time were observed across all patient groups.
- Increased prothrombin consumption was a common finding, with elevated prothrombin index noted in scleroderma and psoriatic arthritis patients.
- A direct relationship was identified between disease severity, affected skin surface area, joint inflammation activity, and the degree of hemostasis impairment.
Impact:
- Highlights potential hemostatic complications in these skin and joint diseases.
- Suggests hemostasis monitoring may be valuable for assessing disease activity and severity.
- Provides insights into the systemic nature of these conditions, involving coagulation pathways.