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[Cataract--clinic and pathology].

Y Fujinaga1

  • 1Department of Ophthalmology, Tottori University School of Medicine.

Nippon Ganka Gakkai Zasshi
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

Aging significantly impacts lens health, contributing to senile cataracts. While some agents showed no effect on rat lens cell density, glutathione and pirenoxin demonstrate potential as anti-cataract therapies, offering hope for future treatments.

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Area of Science:

  • Ophthalmology
  • Gerontology
  • Biochemistry

Background:

  • Senile cataracts are a significant cause of vision impairment, with aging processes affecting lens structure and function.
  • Understanding the mechanisms of cataract formation is crucial for developing effective interventions.

Observation:

  • Clinicopathological studies on human senile cataracts reveal age-related changes in the lens equatorial region and surrounding environment.
  • Wistar rat cataracts share similarities with human senile cataracts, validating their use as a research model.
  • Studies on cultured lens epithelial cells indicate that selenite exposure disrupts cellular defense mechanisms, decreasing superoxide dismutase (SOD) activity and glutathione (GSH) levels.

Findings:

  • Investigated agents like vitamin E, ARI, EPC, catalin, and reduced catalin showed no statistically significant effect on lens epithelial cell density in senile Wistar rats.

Related Experiment Videos

  • However, in cultured cells, glutathione and pirenoxin effectively maintained normal SOD activity when exposed to selenite, suggesting their potential as anti-cataract agents.
  • Cataract incidence varied significantly among rat strains, with stroke-prone spontaneously hypertensive rats (SHRSP) exhibiting a high prevalence of nuclear opacity.

    • Implications:

    • The Wistar rat model serves as a valuable tool for studying human senile cataracts.
    • Glutathione and pirenoxin show promise as therapeutic agents for preventing or treating cataracts.
    • Further research is needed to elucidate the mechanisms by which aging and various factors contribute to cataractogenesis.