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Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Related Experiment Video

Updated: May 20, 2026

Visualizing Low-Abundance Proteins and Post-Translational Modifications in Living Drosophila Embryos via Fluorescent Antibody Injection

Visualizing Low-Abundance Proteins and Post-Translational Modifications in Living Drosophila Embryos via Fluorescent Antibody Injection

Published on: January 19, 2024

EGFR-dependent network interactions that pattern Drosophila eggshell appendages.

David S A Simakov¹, Lily S Cheung, Len M Pismen

¹Department of Chemical Engineering, Technion-Israel Institute of Technology, Israel.

Development (Cambridge, England)

|July 12, 2012

Summary

This summary is machine-generated.

Drosophila oogenesis uses Epidermal Growth Factor Receptor (EGFR) signaling to pattern follicle cells for eggshell appendage formation. A revised mathematical model proposes sequential feed-forward loops and juxtacrine signals establish these structures.

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Last Updated: May 20, 2026

Visualizing Low-Abundance Proteins and Post-Translational Modifications in Living Drosophila Embryos via Fluorescent Antibody Injection

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Published on: January 19, 2024

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Published on: March 13, 2015

Live-imaging of the Drosophila Pupal Eye

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Published on: January 12, 2015

Area of Science:

Developmental biology
Cell signaling
Genetics

Background:

Drosophila melanogaster utilizes Epidermal Growth Factor Receptor (EGFR) signaling for multiple developmental processes.
Follicular epithelium patterning during oogenesis is critical for eggshell appendage formation.
Existing models fail to fully explain the coordinated expression of broad (br) and rhomboid (rho) genes in appendage primordia.

Purpose of the Study:

To develop a revised mathematical model for follicle cell patterning in Drosophila oogenesis.
To elucidate the mechanisms underlying the coordinated expression of br and rho genes.
To investigate the role of EGFR signaling in establishing dorsal appendage primordia.

Main Methods:

Mathematical modeling of follicle cell patterning.
Computational analysis of gene expression patterns.
Simulation of mutant phenotypes.

Main Results:

A revised computational model proposes sequential feed-forward loops and juxtacrine signals activated by EGFR signaling gradients.
The model successfully describes pattern formation in various mutant contexts.
The model highlights the dynamic interplay between EGFR and Notch pathways.

Conclusions:

Sequential feed-forward loops and juxtacrine signaling, driven by EGFR gradients, are proposed mechanisms for dorsal appendage primordia establishment.
The revised model provides a framework for understanding complex gene interactions in oogenesis.
Further research is needed to explore the dynamic interactions between EGFR and Notch pathways.