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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
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Related Experiment Video

Updated: May 20, 2026

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform

Gene Expression Profiling of Infecting Microbes Using a Digital Bar-coding Platform

Published on: January 13, 2016

Protocol for gene expression profiling using DNA microarrays in Neisseria gonorrhoeae.

Lydgia A Jackson¹, David W Dyer

¹Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Lydgia-jackson@ouhsc.edu

Methods in Molecular Biology (Clifton, N.J.)

|July 12, 2012

Summary

This study details using a custom oligonucleotide microarray for Neisseria spp. gene expression profiling. This method offers a cost-effective approach for understanding host-pathogen interactions.

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Bacterial Gene Expression Analysis Using Microarrays

Bacterial Gene Expression Analysis Using Microarrays

Published on: May 28, 2007

Area of Science:

Molecular Biology
Microbiology
Genomics

Background:

DNA microarrays are essential tools for studying gene expression in molecular biology.
Understanding Neisseria spp. biology and host interactions is crucial.
Choosing the right microarray platform requires careful consideration of organism availability, cost, and technical requirements.

Purpose of the Study:

To describe the application of a custom 12K CombiMatrix ElectraSense™ oligonucleotide microarray.
To assess global gene expression profiles in Neisseria spp.

Main Methods:

Utilized a custom 12K CombiMatrix ElectraSense™ oligonucleotide microarray format.
Applied microarray technology for gene expression profiling in Neisseria spp.

Main Results:

Successfully implemented a custom microarray for Neisseria spp. gene expression analysis.
Demonstrated the utility of oligonucleotide microarrays for global gene expression studies in Neisseria spp.

Conclusions:

Custom oligonucleotide microarrays provide a viable and potentially cost-effective solution for Neisseria spp. gene expression profiling.
This approach enhances the understanding of Neisseria spp. biology and host interactions.