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Updated: Jan 3, 2026

Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease
Published on: April 19, 2015
Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D
Ashrafali Mohamed Ismail1, Xiaohong Zhou1, David W Dyer2
1Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Abstract:
Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.
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