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Related Experiment Video

Updated: May 20, 2026

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

Transcutaneous spinal direct current stimulation.

Filippo Cogiamanian1, Gianluca Ardolino, Maurizio Vergari

  • 1Unità Operativa di Neurofisiopatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan, Italy.

Frontiers in Psychiatry
|July 12, 2012
PubMed
Summary
This summary is machine-generated.

Transcutaneous spinal direct current stimulation (tsDCS) non-invasively modulates spinal cord activity. This technique shows potential for managing pain and other conditions by altering spinal excitability.

Keywords:
painspinal cordtranscranial direct current stimulationtranscutaneous spinal direct current stimulation

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Area of Science:

  • Neuroscience
  • Neuromodulation
  • Spinal Cord Stimulation

Background:

  • Transcranial direct current stimulation (tDCS) modulates cortical excitability.
  • There is a need for non-invasive methods to modulate spinal cord function.

Purpose of the Study:

  • To assess the effects of thoracic transcutaneous spinal DC stimulation (tsDCS) on spinal cord function.
  • To explore tsDCS as a potential therapeutic tool.

Main Methods:

  • Administered thoracic anodal tsDCS to healthy subjects.
  • Measured somatosensory evoked potentials (SEPs) following posterior tibial nerve (PTN) stimulation.
  • Assessed H-reflex dynamics and laser evoked potentials (LEPs).

Main Results:

  • Thoracic anodal tsDCS depressed the cervico-medullary PTN-SEP component (P30).
  • tsDCS modulated H-reflex dynamics, flexion reflexes, and LEPs.
  • Increased pain tolerance was observed in healthy subjects.

Conclusions:

  • Non-invasive spinal cord stimulation (tsDCS) influences human spinal function.
  • tsDCS modulates activity in sensory and motor pathways.
  • tsDCS offers a potential non-invasive therapeutic approach for conditions like pain.