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Updated: May 20, 2026
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation
Yen-Chih Wang1, Mark D Distefano
1Department of Chemistry, University of Minnesota, 207 Pleasant Street, S. E. Minneapolis, MN 55455, USA.
Chemical Communications (Cambridge, England)
|July 12, 2012
Abstract:
Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificity of protein farnesyltransferase from S. cerevisiae.
