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Updated: May 20, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Nail psoriasis: a review.

Eugene S T Tan1, Wei-Sheng Chong, Hong Liang Tey

  • 1National Skin Centre, Singapore. eugenetan@nsc.gov.sg

American Journal of Clinical Dermatology
|July 13, 2012
PubMed
Summary
This summary is machine-generated.

Nail psoriasis affects many with psoriasis or psoriatic arthritis, potentially causing severe nail damage and functional issues. Early, individualized treatment is key to managing this common condition.

Related Experiment Videos

Last Updated: May 20, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology
  • Rheumatology

Background:

  • Nail psoriasis is prevalent, affecting up to 50% of psoriasis patients and 90% of psoriatic arthritis patients.
  • Untreated nail psoriasis can lead to debilitating nail disease and significant functional impairment.

Purpose of the Study:

  • To summarize the clinical presentation, assessment tools, and treatment strategies for nail psoriasis.
  • To highlight the importance of individualized treatment based on disease severity and patient factors.

Main Methods:

  • Review of clinical signs including pitting, onycholysis, oil drop discoloration, subungual hyperkeratosis, and splinter hemorrhages.
  • Utilization of the modified Nail Psoriasis Severity Index (mNAPSI) for severity grading and the Nail Psoriasis Quality of Life Scale (NPQ10) for impact assessment.

Main Results:

  • Common signs include nail pitting and onycholysis; assessment tools like mNAPSI and NPQ10 aid in evaluation.
  • Topical and intralesional therapies offer safe and effective treatment but face adherence and pain challenges.
  • Systemic therapies, including oral retinoids and biologics (TNF-α inhibitors, ustekinumab), are options for severe or refractory cases.

Conclusions:

  • Individualized treatment plans are essential for managing nail psoriasis.
  • A range of therapeutic options exist, from topical agents to systemic and biologic treatments.
  • Effective management can mitigate functional impairment and improve quality of life for patients.