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A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

Decreased functional connectivity by aging is associated with cognitive decline.

Keiichi Onoda¹, Masaki Ishihara, Shuhei Yamaguchi

¹Shimane University, Japan.

Journal of Cognitive Neuroscience

|July 13, 2012

Summary

Aging impairs brain networks, particularly the salience network, leading to cognitive decline in older adults. This study reveals age-related disruptions in functional connectivity and internetwork communication.

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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Neuroscience
Cognitive Aging Research
Brain Network Analysis

Background:

Aging is associated with cognitive decline.
Previous research primarily focused on the default mode network's disruption.
Other resting-state brain networks' roles in aging remain underexplored.

Purpose of the Study:

To investigate the relationship between aging, cognitive decline, and resting-state brain network disruptions.
To examine functional connectivity within and between brain networks in aging.
To identify specific networks affected by aging and their correlation with cognitive function.

Main Methods:

Functional magnetic resonance imaging (fMRI) to measure resting-state brain activity.
Independent component analysis (ICA) to evaluate functional connectivity.
Correlation analysis between network connectivity and cognitive abilities.

Main Results:

Decreased functional connectivity within the salience network (bilateral insula, anterior cingulate cortex) with aging.
Impaired salience network connectivity correlated with reduced cognitive abilities.
Reduced internetwork connectivity (e.g., salience to auditory, default mode to visual) observed in older adults.

Conclusions:

Aging impacts multiple resting-state networks, notably the salience network, beyond the default mode network.
Aging disrupts internetwork connectivity patterns.
Salience network disruption is a significant factor in age-related cognitive decline.