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Inotropic activities of imidazopyridines
P Barraclough1, J W Black, D Cambridge
1Department of Medicinal Chemistry, Wellcome Research Laboratories, Beckenham, Kent, U.K.
Archiv Der Pharmazie
|August 1, 1990
Abstract:
A series of 2-substituted 1H-imidazo[4,5-b]pyridines and the isomeric 1H-imidazo[4,5-c]pyridine derivatives has been prepared and evaluated as inotropic agents. The 1H-imidazo-[4,5-b] derivatives were found to be consistently more potent than their isomers in the [4,5-c] series in isolated guinea pig papillary muscle preparations. Structure-activity relationships and the species-dependence of inotropic potencies are discussed.