Related Experiment Video
Updated: May 20, 2026

Methods to Inhibit Bacterial Pyomelanin Production and Determine the Corresponding Increase in Sensitivity to Oxidative Stress
Published on: August 31, 2015
6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp
Toshikazu Komoda1, Masazumi Nishikawa
1School of Food, Agricultural, and Environmental Sciences, Miyagi University, Sendai, Miyage, Japan. komoda@myu.ac.jp
Abstract:
A new lipoxygenase inhibitor, 6'-hydroxyoxosorbicillinol (1, C(14) H(16)O(6)), was identified from a culture of Penicillium sp. A known compound, oxosorbicillinol (2, C(14)H(16)O(5)), was also isolated. Compound 1 showed an approximately 10 times greater inhibitory effect on soybean lipoxygenase (IC(50), 16 µM) than 2 (IC(50), 150 µM), and also showed prostaglandin D(2) (PGD(2)) and leucotriene B(4) (LTB(4)) release suppression activity (IC(50), 10 µM for PGD(2) and 100 µM for LTB(4)).
Related Concept Videos
Production of Antibiotics
Inhibitors of Gram-positive Cell Wall Synthesis
Formation of Lipopolysaccharides

