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Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
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Office-based opioid dependence treatment.

James Colson1, Standiford Helm, Sanford M Silverman

  • 1West Virginia University Hospitals, Morgantown, WV 26506, USA. colsonj@wvuhealthcare.com

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Summary
This summary is machine-generated.

Opioid antagonists and partial agonists are effective in preventing opioid tolerance and dependence. These medications are revolutionizing opioid dependence therapy, offering new office-based treatment options.

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Public Health

Background:

  • Increasing prevalence of opioid misuse and abuse in chronic non-cancer pain management.
  • Development of opioid-related drugs with altered mu receptor activity.
  • Opioid antagonists and partial agonists modulate tolerance and dependence.

Purpose of the Study:

  • Evaluate therapeutic utility of opioid antagonists and partial agonists.
  • Assess their role in preventing opioid tolerance and dependence.
  • Focus on office-based practice applications.

Main Methods:

  • Narrative review of current literature (2008-2010).
  • Computerized database searches (PubMed, EMBASE, BioMed, Cochrane).
  • Inclusion of reviews, studies, and FDA/manufacturer data.

Main Results:

  • Opioid antagonists and partial agonists are used in abuse deterrent strategies.
  • These agents aid in opioid detoxification and withdrawal management.
  • Buprenorphine and buprenorphine/naloxone have transformed therapy.

Conclusions:

  • Opioid dependency remains a significant public health issue.
  • DATA 2000 and FDA-approved medications revolutionized treatment.
  • Office-based buprenorphine treatment challenges traditional methadone maintenance.