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Protective capacity of virus-specific T cell receptor-transduced CD8 T cells in vivo

Katja Mueller1, Anne von Mässenhausen, Ulrike Aichele

  • 1Institute of Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany.

Journal of Virology
|July 13, 2012
PubMed

The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.

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