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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Tianma modulates blood vessel tonicity
Lin Feng1, Arulmani Manavalan, Manisha Mishra
1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, 637551, Singapore.
The Open Biochemistry Journal
|July 13, 2012
Summary
Tianma enhances blood vessel relaxation and elasticity by altering aortic protein metabolism. This traditional Chinese medicine may offer a novel approach for treating cardiovascular diseases.
Area of Science:
- Pharmacology
- Molecular Biology
- Cardiovascular Research
Background:
- Traditional Chinese Medicine (TCM) like Tianma is used for hypertension and heart conditions.
- Understanding Tianma's molecular mechanisms in cardiovascular health is crucial.
Purpose of the Study:
- To investigate Tianma's effects on vascular function and aortic protein metabolism.
- To elucidate the molecular basis of Tianma's therapeutic potential in cardiovascular diseases.
Main Methods:
- Long-term administration of Tianma to rats.
- Assessment of acetylcholine-induced vasorelaxation in aortic rings.
- Proteomic analysis using isobaric tag for relative and absolute quantification (iTRAQ) to identify protein expression changes.
Main Results:
- Tianma treatment enhanced vasorelaxation against KCl and phenylephrine-induced contractions.
- Proteomic analysis revealed down-regulation of contractile proteins (e.g., Acta2) and up-regulation of extracellular matrix glycoproteins (e.g., Fbln5) and anti-thrombotic proteins (e.g., Anxa2) in aortic tissue.
- Tianma modulated aortic protein expression, impacting vascular smooth muscle contraction, elasticity, and arterial structure.
Conclusions:
- Tianma exerts vasodilatory effects by inhibiting vascular smooth muscle contraction and improving blood vessel elasticity.
- Tianma regulates aortic proteome metabolism, suggesting its potential as a novel therapeutic agent for cardiovascular diseases.
- Further research into Tianma's molecular targets could lead to new herbal medicine strategies for heart conditions.
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