Congenital leukemia with leukemia cutis: a case report

Congenital leukemia is a rare malignancy. Most of the neonatal cases reported have acute nonlymphoblastic leukemia. A number of chromosomal translocations and deletions have been found carrying an unfavorable prognosis. We report a newborn with congenital leukemia with leukemia cutis. The patient died before chemotherapy was started. The chromosome analysis showed 46, XY, t (4:11) (q21;q23). FISH for 11q23 MLL gene rearrangement showed positivity in 58% of interphase cells examined. Flow cytometry was reported with precursor B-cell acute lymphoblastic leukemia. This is a rare case of congenital leukemia with findings associated with poor prognosis.