Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Direct immunofluorescence staining patterns compared between oral and cutaneous lichen planus.

Clinical and experimental dermatology·2021
Same author

European Guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology - Part II.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology - Part I.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Humeral shaft butterfly fractures managed with intramedullary nail: could the third fragment features predict the fracture healing time?

Journal of biological regulators and homeostatic agents·2020
Same author

The sentinel node biopsy has not come of age.

The British journal of dermatology·2019
Same author

Oral Mucosal Injury Caused by Targeted Cancer Therapies.

Journal of the National Cancer Institute. Monographs·2019
Same journal

Structural Validity and Factorial Analysis of the Brazilian Oral Health Impact Profile for Temporomandibular Disorders Instrument.

Oral diseases·2026
Same journal

Effects of Pistacia lentiscus Leaf-Twig and Resin (Mastic) Oils on Salivary Flow in Healthy Individuals.

Oral diseases·2026
Same journal

Oral Delivery of Bioencapsulated CTB-Pro-IGF-1 Enhances Bone Regeneration in a Pre-Clinical Rat Model of Jaw Osteoradionecrosis.

Oral diseases·2026
Same journal

Trends in Stage and Age at Diagnosis of Oral Squamous Cell Carcinoma Over Time: A Systematic Review and Meta-Analysis.

Oral diseases·2026
Same journal

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders.

Oral diseases·2026
Same journal

Authors' Reply "Synchronous Soft-Tissue Lesions in the Oral Cavity in an Adolescent".

Oral diseases·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Urban legends series: lichen planus.

L Baccaglini1, K Thongprasom, M Carrozzo

  • 1Department of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand Department of Oral Medicine, Centre for Oral Health Research, Newcastle University, Newcastle upon Tyne, UK Department of Dermatology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.

Oral Diseases
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

Hepatitis C virus (HCV) infection is linked to oral lichen planus (OLP). Screening for HCV in at-risk OLP patients is advised, while routine amalgam removal is not recommended. New topical treatments show promise.

Keywords:
amalgamhepatitislichen planusmercurysystematic reviewtreatment

More Related Videos

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Related Experiment Videos

Last Updated: May 20, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
05:44

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Area of Science:

  • Oral Medicine
  • Dermatology
  • Infectious Diseases

Background:

  • Oral lichen planus (OLP) is a common inflammatory condition affecting the oral mucosa and skin.
  • The etiology and optimal management of OLP remain subjects of ongoing research and debate.
  • Key controversies include the role of hepatitis C virus (HCV), dental amalgam restorations, and emerging therapies.

Purpose of the Study:

  • To critically evaluate the association between HCV infection and OLP pathogenesis.
  • To determine the necessity of HCV screening for OLP patients.
  • To assess the efficacy of amalgam restoration removal and explore novel OLP treatments.

Main Methods:

  • Extensive literature searches were conducted to gather evidence on four controversial aspects of OLP.
  • Meta-analyses and clinical study data were reviewed to synthesize findings.
  • Evidence quality was assessed to draw conclusions on controversial topics.

Main Results:

  • Robust evidence indicates an association between HCV infection and OLP, suggesting a potential role in pathogenesis.
  • Prudent HCV antibody screening using ELISA is recommended for OLP patients at significant risk.
  • No routine benefit from amalgam restoration replacement for OLP patients was found, though targeted replacement may help a subset.
  • Topical pimecrolimus, aloe vera, and oral curcuminoids show weak evidence of efficacy for OLP treatment.

Conclusions:

  • HCV infection is associated with OLP, warranting consideration in diagnosis and management.
  • Selective HCV screening in at-risk OLP populations is advisable.
  • Amalgam replacement is not routinely indicated for OLP, but individualized assessment may be beneficial.
  • Emerging topical treatments offer potential new therapeutic avenues for OLP management.