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Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
Published on: January 18, 2017
Cancer and inflammation: an aspirin a day keeps the cancer at bay
1Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany. Maria.Mione@kit.edu
Abstract:
Live imaging of the interactions between oncogene-transformed cells and leukocytes in zebrafish reveals that PGE(2) promotes the survival and proliferation of cancer cells. Non-steroid anti-inflammatory drugs, like aspirin, are the effective inhibitors of PGE(2) production and could be used with other anti-tumor agents in the treatment of cancer.
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