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[Liver protective effect of Lentinula edodes mycelia(LEM)]
1Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 14, 2012
Summary
Lentinula edodes mycelia (LEM) extracts show significant hepatoprotective effects against acute and chronic liver injury. These mushroom extracts may help alleviate chemotherapy side effects and prevent liver cancer progression.
Area of Science:
- Mycology
- Pharmacology
- Hepatology
Background:
- Lentinula edodes mycelia (LEM) extracts contain bioactive compounds like carbohydrates, proteins, phenolics, and lignin digests.
- These compounds exhibit diverse physiological activities, including significant hepatoprotective properties.
Purpose of the Study:
- To investigate the hepatoprotective effects of Lentinula edodes mycelia (LEM) extracts.
- To evaluate the potential of LEM in mitigating liver injury and associated conditions.
Main Methods:
- Assessing hepatoprotective activities in animal models with acute liver injury induced by concanavalin A or D-galactosamine.
- Evaluating the suppression of liver fibrosis and inflammation in mice with chronic liver injury induced by carbon tetrachloride.
- Analyzing the specific contributions of vanillic acid, syringic acid, and low-molecular-weight lignin within LEM.
Main Results:
- LEM demonstrated significant hepatoprotective effects in acute liver injury models.
- LEM suppressed liver fibrosis and inflammation in chronic liver injury models.
- Specific compounds like vanillic acid, syringic acid, and low-molecular-weight lignin contributed to the observed hepatoprotective and cytoprotective effects.
Conclusions:
- LEM possesses potent anti-oxidation and anti-inflammation activities, conferring significant hepatoprotection.
- LEM holds potential for alleviating chemotherapy side effects and preventing liver cancer progression in chronic hepatitis patients.