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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
Cross-reactivity00:42

Cross-reactivity

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

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Related Experiment Video

Updated: May 20, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Cross-presentation by dendritic cells.

Olivier P Joffre1, Elodie Segura, Ariel Savina

  • 1INSERM U932, 26 Rue d'Ulm, 75005 Paris, France.

Nature Reviews. Immunology
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

Cross-presentation of antigens by dendritic cells (DCs) is crucial for CD8(+) T cell immunity. This review covers intracellular mechanisms, DC subset specialization, and immunotherapy applications for cross-presentation.

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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Cross-presentation is vital for initiating CD8(+) T cell responses by displaying exogenous antigens on MHC class I molecules.
  • Specific dendritic cell (DC) subsets perform in vivo cross-presentation by adapting their endocytic and phagocytic pathways.

Purpose of the Study:

  • To summarize recent advances in understanding the intracellular mechanisms of cross-presentation.
  • To discuss the role of cross-presentation in immunity and tolerance, considering DC subset specialization.
  • To review current immunotherapy strategies leveraging cross-presentation.

Main Methods:

  • Literature review and synthesis of recent research findings.
  • Analysis of intracellular pathways involved in cross-presentation.
  • Discussion of DC subset specialization and its implications.

Main Results:

  • Recent advances have elucidated complex intracellular mechanisms governing cross-presentation.
  • DC subset specialization influences the efficiency and context of cross-presentation.
  • Cross-presentation plays a dual role in both immunity and tolerance.

Conclusions:

  • Understanding cross-presentation mechanisms is key to harnessing its potential in immunotherapy.
  • Targeting DC subsets offers a promising strategy for enhancing immunotherapeutic outcomes.
  • Further research into DC specialization can optimize cross-presentation-based therapies.