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[Thyroid hormone profile in breast cancer patients in postmenopause]
Sandro José Conde1, Renata de Azevedo Melo Luvizotto, Maria Teresa de Síbio
1Departamento de Clínica Médica, Universidade Estadual Paulista "Júlio de Mesquista Filho", Botucatu, SP, Brasil. condesan@yahoo.com.br
Objective:
The aim of this study was to determine thyroid hormone (TH) profile in postmenopausal patients with breast cancer (BC).
Subjects And Methods:
12 CaM patients stages I or II, without interventions that could interfere with tumor progression were selected, as well as and a control group with 18 postmenopausal women without CaM. We measured serum anti-thyroperoxidase antibody (TPOAB), thyroid-stimulating hormone (TSH), free thyroxine (T4L), estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH), before and after surgery, besides immunohistochemistry for estrogen (ER) and progesterone (PR) receptors.
Results:
Four patients with CaM showed changes in thyroid hormone profile: two had hyperthyroidism, one hypothyroidism, and one was positive for TPO-AB. All of them positive for ER and PR. TSH levels in breast cancer patients were not different from levels found in the control group (1.89 ± 1.56 vs. 2.86 ± 3.12 mIU/mL), but the levels of T4L in patients with CaM were statistically higher than those of the control group (1.83 ± 0.57 vs. 1.10 ± 0.20 ng/dL).
Conclusion:
These results reinforce the need for assessment of thyroid status in CaM patients, since in the absence of E2, changes in clinical HTs can act in E2-controlled processes.
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