Related Experiment Videos

Association between neutrophil to lymphocyte ratio and severity of coronary artery disease

Hasan Kaya1, Faruk Ertaş, Yahya İslamoğlu

  • 11Department of Cardiology, Dicle University Faculty of Medicine, Diyarbakır, Turkey.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|July 14, 2012
PubMed

Insights

The neutrophil-to-lymphocyte ratio (NLR) is elevated in patients with severe coronary atherosclerosis. This blood marker can help predict the severity of coronary artery disease and aid in cardiac risk stratification.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Coronary atherosclerosis is a leading cause of cardiovascular disease.
  • Identifying reliable biomarkers for disease severity is crucial for patient management.
  • The neutrophil-to-lymphocyte ratio (NLR) is an emerging inflammatory marker.

Purpose of the Study:

  • To investigate the association between NLR and the severity of coronary atherosclerosis.
  • To evaluate NLR's potential as a predictor of severe coronary artery disease.

Main Methods:

  • Retrospective analysis of 172 patients undergoing coronary angiography.
  • Comparison of NLR levels between control, mild, and severe atherosclerosis groups.
  • Correlation analysis between NLR and Gensini score.
  • Multivariate analysis to identify independent predictors of severe atherosclerosis.

Main Results:

  • NLR was significantly higher in patients with severe atherosclerosis compared to mild and control groups (P < .001).
  • NLR showed a significant positive correlation with the Gensini score.
  • A NLR cutoff of 2.5 predicted severe atherosclerosis with 62% sensitivity and 69% specificity.
  • High NLR levels, glucose, and low high-density lipoprotein were independent predictors of severe atherosclerosis.

Conclusions:

  • NLR is a valuable and independent predictor of severe coronary atherosclerosis.
  • NLR may improve cardiac risk stratification in patients with coronary artery disease.
  • Further research is warranted to validate NLR's role in clinical practice.

Keywords:
Gensini scorecoronary artery diseaseneutrophil to lymphocyte ratio

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Odds Ratio01:09

Odds Ratio

The odds ratio (OR) is a statistical measure used extensively in epidemiology and research to quantify the strength of association between exposure and outcome across different groups. Unlike relative risk, which compares the probabilities of an event occurring, the odds ratio compares the odds of an event occurring in the exposed group to the odds of it occurring in the unexposed group. The odds, in this context, are calculated as the probability of the event happening divided by the...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...