Association of circulating endothelial progenitor cells (CD14+-EPC) with renal function in patients with coronary
Gui-Qiong Li1, Yan Yang, Da-Zhi Ke
11The 2nd affiliated Hospital of Chongqing Medical University, Chongqing, China.
Insights
In patients with coronary artery disease (CAD), lower counts of CD14(+) cells are linked to reduced kidney function. This finding highlights a potential biomarker for renal dysfunction in CAD patients.
Area of Science:
- Cardiovascular Research
- Nephrology
- Immunology
Background:
- Endothelial progenitor cells (EPCs), specifically CD34(+) and CD14(+) subtypes, have been implicated in coronary artery disease (CAD).
- Previous studies explored the association between CD34(+) cells and renal function.
- The relationship between CD14(+) EPCs and renal function in CAD patients remained uninvestigated.
Purpose of the Study:
- To investigate the association between CD14(+) cell counts and renal function in patients diagnosed with coronary artery disease (CAD).
Main Methods:
- A cohort of 242 patients with severe angiographic CAD and 30 healthy controls were analyzed.
- CD14(+) cell enumeration was performed using flow cytometry.
- Glomerular filtration rate (GFR) was assessed, including estimated GFR (eGFR).
Main Results:
- CD14(+) cell counts showed a significant decrease with declining estimated GFR (eGFR) across different ranges (≥90, 60-89, and 30-59 mL/min per 1.73 m²).
- A positive correlation was observed between CD14(+) cell counts and eGFR (r = 0.27, P = 0.03).
- Multivariate linear regression confirmed the significance of this association (P = 0.02).
Conclusions:
- Depletion of CD14(+) cells is significantly associated with renal dysfunction in patients suffering from coronary artery disease (CAD).
- CD14(+) cells may serve as a potential indicator of kidney function decline in the context of CAD.
Background:
The relationships between the endothelial progenitor cells (EPCs)-CD34(+) and CD14(+) and coronary artery disease (CAD) were reported and the association of CD34(+) cells with renal function was studied previously. Another kind EPC-CD14(+) cell and its association with renal function in patients with CAD have not been reported yet. Our aim was to assess CD14(+) cell counts versus renal function in CAD.
Methods And Results:
We studied 242 patients with severe angiographic CAD and 30 healthy control participants. The CD14(+) cells were enumerated by flow cytometry. With lowering glomerular filtration rate (GFR), CD14(+) cell numbers (percentage of lymphocytes, median and interquartile range) decreased: 0.04 (0.03-0.06), 0.03 (0.02-0.05), 0.02 (0.01-0.03) for estimated glomerular filtration rate (eGFR) ≥90, 60 to 89, and 30 to 89 mL/min per 1.73 m(2), respectively (P < .001 for trend). The CD14(+) cell counts correlated with eGFR (r = .27, P = .03). By multivariate liner regression analysis, the difference remains significant (P = .02).
Conclusions:
The CD14(+) cell depletion is associated with renal dysfunction in CAD.
