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Updated: May 20, 2026
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Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
Published on: August 20, 2013
New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a
Shigeru Nakaya1, Saki Mizuno, Hiroki Ishigami
1Faculty of Science, Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan.
Bioscience, Biotechnology, and Biochemistry
|July 14, 2012
Abstract:
The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.
