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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Published on: June 30, 2014

Modifiable comorbidities and disability in multiple sclerosis.

Shannon Overs1, Christina M Hughes, Jodie K Haselkorn

  • 1Department of Neurology, Portland VA Medical Center, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA.

Current Neurology and Neuroscience Reports
|July 14, 2012
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) is a disabling neurological disease. Managing conditions like hypertension, obesity, diabetes, alcohol, and smoking can reduce MS progression and improve quality of life.

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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
05:44

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Published on: October 13, 2023

Area of Science:

  • Neurology
  • Public Health
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) is a prevalent neurological disorder causing early adulthood disability.
  • Comorbid conditions exacerbate MS progression and functional limitations.
  • Modifiable health factors significantly impact MS outcomes.

Purpose of the Study:

  • To investigate the influence of common modifiable health conditions and behaviors on multiple sclerosis progression and disability.
  • To identify key targets for intervention to improve patient outcomes.

Main Methods:

  • Review of existing literature on multiple sclerosis and associated comorbidities.
  • Analysis of data linking hypertension, obesity, diabetes mellitus, alcohol consumption, and smoking to MS severity and disability.
  • Examination of the impact of these factors on daily activities and social participation.

Main Results:

  • Hypertension, obesity, diabetes mellitus, alcohol use, and smoking are associated with increased multiple sclerosis progression.
  • These conditions independently contribute to limitations in activities and social participation for individuals with MS.
  • Early identification and management of these comorbidities show potential for mitigating MS-related disability.

Conclusions:

  • Addressing modifiable health conditions like hypertension, obesity, diabetes, alcohol, and smoking is crucial for managing multiple sclerosis.
  • Effective treatment strategies can improve overall health status, reduce disability, and enhance the quality of life for MS patients.