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Related Experiment Video

Updated: Apr 19, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
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Cognitive Strategy Use for Functional Compensation in Multiple Sclerosis: A Systematic Review.

Rachel Nicholson1, Aaron P Turner2, Elizabeth S Gromisch3

  • 1Department of Physical Medicine and Rehabilitation, University of Rochester Medical Center, Rochester, NY.

Archives of Physical Medicine and Rehabilitation
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Visualization/imagery mnemonics are most used and supported for people with multiple sclerosis (PwMS). These cognitive strategies show promise for improving learning, memory, and processing speed in PwMS.

Keywords:
Cognitive dysfunctionCognitive trainingMindfulnessMultiple sclerosisRehabilitationSystematic review

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Area of Science:

  • Neurorehabilitation
  • Cognitive Psychology
  • Clinical Neurology

Background:

  • Multiple sclerosis (MS) frequently causes cognitive impairments, impacting daily functioning.
  • Compensatory cognitive strategies offer potential interventions for managing these deficits.

Purpose of the Study:

  • To systematically review the evidence for specific compensatory cognitive strategies in people with multiple sclerosis (PwMS).
  • To identify the most frequently used and effective cognitive strategies for PwMS.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, MEDLINE, PsycINFO, and CINAHL databases.
  • Included studies were clinical trials and observational studies of adults with MS using defined cognitive strategies with quantifiable cognitive outcomes.
  • Data extraction and evidence grading were performed by two independent reviewers.

Main Results:

  • Sixty-four studies (n=3,759) were included, with visualization/imagery mnemonics being the most common strategy (34.9%).
  • Attentional, internal memory, and external memory strategies demonstrated small-to-medium improvements in learning and memory.
  • Attentional and relaxation strategies showed small, significant effects on processing speed.

Conclusions:

  • Visualization/imagery mnemonics are the most utilized and evidence-supported cognitive strategy for PwMS.
  • Findings can guide clinicians in selecting appropriate cognitive rehabilitation approaches for individuals with MS.