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Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...

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Severe folate-deficiency pancytopenia.

Viktoriya Clarke1, Simon Weston-Smith

  • 1Department of Medicine, East Sussex Hospital NHS Trust, East Sussex, UK. drvclarke@yahoo.co.uk

BMJ Case Reports
|July 14, 2012
PubMed
Summary

Severe folate deficiency anemia, though rare, can cause pancytopenia. This case highlights rapid recovery with prompt medical intervention, including red cell transfusion and folic acid supplementation.

Area of Science:

  • Hematology
  • Nutritional Science

Background:

  • Folate-deficiency anemia affects approximately 4 in 100,000 individuals.
  • Severe cases with pancytopenia are less common.
  • This report details a significant folate deficiency in a patient with contributing factors like alcoholism and bleeding.

Observation:

  • A 50-year-old female with alcoholism and bleeding presented with severe macrocytic anemia (hemoglobin 2.6 g/dL), leucopenia, and thrombocytopenia.
  • Serum folate levels confirmed severe deficiency (0.8 ng/mL).

Findings:

  • The patient received red blood cell transfusion, platelets, vitamin B12, and oral folic acid.
  • Rapid improvement in leucopenia and thrombocytopenia was observed without complications.

Implications:

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  • This case highlights the importance of recognizing and managing severe folate deficiency, even in patients with comorbidities.
  • Aggressive treatment can lead to rapid hematological recovery and prevent serious complications.