Related Experiment Video
Updated: May 20, 2026
Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens
Published on: December 9, 2022
Pseudomyxoma peritonei of 92 Chinese patients: clinical characteristics, pathological classification and prognostic
Ai-Tao Guo1, Yan-Mi Li, Li-Xin Wei
1Department of Pathology, the General Hospital of the People's Liberation Army, Beijing 100853, China.
Aim:
To assess the clinicopathologic features and its relationship with prognosis of pseudomyxoma peritonei (PMP) in Chinese patients.
Methods:
The clinicopathologic features and follow-up data of 92 patients with PMP were reviewed and retrospectively analyzed. The cases were categorized into three groups: disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and peritoneal mucinous carcinomatosis with intermediate or discordant features (PMCA-I/D). The log-rank test was used to analyze survival for each group and various clinicopathological parameters. Multivariate Cox proportional-hazard models were constructed to determine the important factors associated with survival.
Results:
The median age at diagnosis was 51.9 years (range: 22-76 years). The median follow up was 124 mo. The 3-, 5- and 10-year survival rates were 74.0%, 67.4% and 49.1%, respectively. There were 49 (53.2%) patients with DPAM, 26 (28.3%) with PMCA-I and 17 (18.5%) with PMCA. Patients with DPAM, PMCA-I/D and PMCA exhibited statistically significant difference in survival (P = 0.001). The 3 year survival for DPAM, PMCAI/D and PMCA was 97.0%, 80.0% and 67.0%, respectively; the 5 year survival was 80.0%, 67.0% and 50.0%, respectively; and the 10 year survival was 65.0%, 28.0% and 14.0%, respectively. Survival rate was significantly lowest in patients < 40 age years of age (P = 0.011). Appendiceal tumor and extra-ovarian parenchymal organ involvement were significantly related to overall survival. Patients with appendiceal mucinous adenocarcinoma (MACA) showed the significantly poorer prognosis (P = 0.011). Multivariate analysis showed that pathological classification, age, appendiceal tumor were significant related to overall survival.
Conclusion:
The clinical process "PMP" should be pathologically classified into DPAM, PMCA and PMCA-I/D. Pathological classification, age, appendiceal MACA are survival independent predictors in Chinese patients with PMP.
Insights
Pseudomyxoma peritonei (PMP) prognosis in Chinese patients depends on pathological classification, age, and appendiceal tumor presence. These factors independently predict survival, guiding clinical management for better patient outcomes.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Pseudomyxoma peritonei (PMP) is a rare malignancy characterized by mucinous ascites.
- Accurate clinicopathologic classification is crucial for understanding PMP's behavior and prognosis.
Purpose of the Study:
- To evaluate clinicopathologic features of PMP in Chinese patients.
- To determine the relationship between these features and patient prognosis.
Main Methods:
- Retrospective analysis of 92 PMP patients' clinicopathologic data and follow-up information.
- Categorization into disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA), and intermediate/discordant (PMCA-I/D) groups.
- Survival analysis using log-rank tests and multivariate Cox proportional-hazard models.
Main Results:
- DPAM, PMCA-I/D, and PMCA groups showed significant differences in survival rates (P=0.001).
- Younger age (<40 years), appendiceal tumors, and extra-ovarian parenchymal organ involvement were associated with poorer survival.
- Appendiceal mucinous adenocarcinoma (MACA) correlated with significantly worse prognosis (P=0.011).
Conclusions:
- PMP should be pathologically classified into DPAM, PMCA, and PMCA-I/D categories.
- Pathological classification, patient age, and appendiceal MACA are independent predictors of survival in Chinese PMP patients.
