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Ga-labeling of immunoglobulin G with high specific radioactivity
T Furukawa1, Y Fujibayashi, M Fukunaga
1Department of Health Chemistry, Kansai Medical University, Osaka, Japan.
Chemical & Pharmaceutical Bulletin
|August 1, 1990
Abstract:
To obtain radiogallium labeled immunoglobulin G with a high specific radioactivity for in vitro use, a 67Ga source was purified by extraction from 67Ga-gallium citrate with butyl acetate, and a 67Ga-labeling solution was produced. This solution was then used to label a deferoxamine-immunoglobulin G conjugate. Both a very high specific radioactivity (872 +/- 56 MBq/mg) and a high labeling efficiency (94.0%) were achieved.