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Eosinophilic granuloma of bone: two case reports
Katsuhiko Oguro1, Hidemasa Sakai, Masato Arai
1Department of Pediatrics, Shizuoka Municipal Hospital, Shizuoka, Japan. ogurom@vega.ocn.ne.jp
Brain & Development
|July 17, 2012
Summary
Eosinophilic granuloma (EG) can present unusually in children, affecting the skull and spine. Recognizing these rare presentations is crucial for timely diagnosis and treatment of this bone disorder.
Area of Science:
- Pediatric Oncology
- Skeletal Pathology
- Radiology
Background:
- Eosinophilic granuloma (EG) is typically a benign, self-limiting bone disorder.
- However, EG can exhibit diverse and atypical clinical presentations.
Observation:
- Case 1: A 14-year-old girl presented with headache and a progressive parietal bone swelling, revealing an osteolytic lesion with extracranial and epidural extension on CT and MRI.
- Case 2: A 1.9-year-old boy developed spastic paraplegia due to a spinal tumor compressing the cord and destroying vertebral elements.
Findings:
- Both cases were diagnosed as EG via pathological examination after surgical resection.
- Immunohistochemistry in Case 1 indicated accelerated tumor cell growth (Ki-67).
Implications:
- EG should be considered in the differential diagnosis of osteolytic bone lesions, even with aggressive clinical features.
- These cases highlight the protean nature of EG, emphasizing the need for vigilance in pediatric bone pathology.
