Related Experiment Video
Updated: May 20, 2026

OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
Published on: May 9, 2021
Encountering premature ovulation during controlled ovarian hyperstimulation in IVF/ICSI cycles
Frank Shao-Ying Wu1, Robert Kuo-Kuang Lee, Yuh-Ming Hwu
1Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan.
Objective:
To report successful pregnancy outcomes in three cases of documented premature ovulation in intracytoplasmic sperm injection (ICSI) cycles.
Case Report:
Three cases of premature ovulation were noted during the oocyte retrieval procedures in in vitro fertilization (IVF)/ICSI cycles with gonadotropin-releasing hormone antagonist protocol. Immature oocytes were aspirated from the remaining small and medium-sized follicles with in vitro maturation performed in two cases. All three cases achieved successful pregnancy with documented live birth after ICSI.
Conclusion:
This is the first ever report of successful pregnancy outcome after documented premature ovulation. Fertilizable oocytes and successful pregnancies can still be obtained from the remaining small and medium-sized follicles after premature ovulation and used for ICSI.
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