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Endosomal crosstalk: meeting points for signaling pathways
Máté Pálfy1, Attila Reményi, Tamás Korcsmáros
1Department of Genetics, Eötvös Loránd University, Pázmány P. s. 1/C, Budapest, H-1117, Hungary.
Trends in Cell Biology
|July 17, 2012
Summary
Endosomes regulate cell signaling by facilitating crosstalk between pathways. Researchers identified novel scaffold proteins on endosomes that mediate this signaling crosstalk, offering potential therapeutic targets.
Area of Science:
- Cell Biology
- Molecular Signaling
- Proteomics
Background:
- Endocytosis typically downregulates incoming signals.
- Signaling endosomes can act as platforms for signal pathway crosstalk.
- Endosome-associated scaffold proteins are hypothesized to mediate this crosstalk.
Purpose of the Study:
- To review the role of endosomes in signaling crosstalk.
- To identify novel endosomal scaffold proteins mediating crosstalk between signaling pathways.
Main Methods:
- Proteome-wide in silico analysis.
- Assessment of endosome-binding properties.
- Evaluation of the capacity to recruit signaling proteins from multiple pathways.
Main Results:
- An extended list of putative crosstalk-mediating endosomal scaffolds was generated.
- The study provides a computational approach to identify such scaffolds.
Conclusions:
- Endosomal crosstalk is a key regulator of pathway communication.
- Scaffold proteins mediating endosomal crosstalk represent potential targets for drug development and synthetic biology.
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