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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Updated: May 20, 2026

Primary Culture of Dental Pulp Stem Cells

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Stem cells in dentistry--part I: stem cell sources.

Hiroshi Egusa¹, Wataru Sonoyama, Masahiro Nishimura

¹Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan. egu@dent.osaka-u.ac.jp

Journal of Prosthodontic Research

|July 17, 2012

Summary

Oral tissues are a rich source of stem cells for regenerative dentistry. This review explores intra- and extra-oral stem cells for clinical applications and therapeutic potential.

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Published on: November 24, 2012

Area of Science:

Dentistry
Regenerative Medicine
Stem Cell Biology

Background:

Adult mesenchymal stem/stromal cells (MSCs) are found in oral and maxillofacial tissues.
Oral tissues offer a promising source for stem cells, including induced pluripotent stem (iPS) cells.
Stem cell therapies are gaining traction in clinical dentistry for tissue regeneration.

Purpose of the Study:

To review intra- and extra-oral tissue-derived stem cells.
To discuss clinical availability and dental applications of these stem cells.
To evaluate stem cell sources for regenerative dentistry based on differentiation, accessibility, and immunomodulatory properties.

Main Methods:

Literature review of stem cell types from oral tissues.
Analysis of clinical availability and dental applications.
Assessment of stem cell properties relevant to regenerative dentistry.

Main Results:

Various intra- and extra-oral tissues harbor stem cells with therapeutic potential.
Oral stem cells are suitable for generating genetically reprogrammed cells like iPS cells.
Stem cell sources are evaluated for differentiation capacity, accessibility, and immunomodulatory effects.

Conclusions:

Oral tissues represent a valuable and accessible source for stem cells in regenerative dentistry.
Stem and mucosal cells from the mouth are ideal for reprogramming into iPS cells.
Further research into stem cell properties will advance tissue engineering therapies in dentistry.