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Three new triterpenoid saponins from root of Gardenia jasminoides Ellis
Jing Wang1, Jincai Lu, Chongning Lv
1School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Box 79, Shenyang, Liaoning Province, 110016, PR China.
Abstract:
Three new compounds (Gardeniside A-C), 11α,12α-epoxy-3β-[(O-β-D-glucuronopyranoside-6'-O-methly ester)oxy]olean-28,13-olide (1), siaresinolic acid 3-O-β-D-glucuronopyranoside-6'-O-methly ester (2), and 3-O-β-D- glucuronopyranoside-6'-O-methly ester-siaresinolic acid-28-O-β-D- glucopyranoside (3), with seven known compounds oleanolic acid 3-O-β-D- glucuronopyranoside-6'-O-methly ester (4), oleanolic acid 3-O-β-D- glucuropyranoside (5), hederagenin 3-O-β-D- glucuronopyranoside-6'-O- methly ester (6), chikusetsusaponin IVa methyl ester (7), chikusetsusaponin (8), chikusetsusaponin IVa butyl ester (9), siaresinolic acid 28-o-β-d-glucopyranosyl ester (10) were isolated from the root of Gardenia jasminoides Ellis. Six compounds (1, 4-7, and 9) showed cytotoxic activities against HeLa, A549, MCF-7 and A354-S2 cell lines.
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