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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Related Experiment Video

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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

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Published on: May 19, 2015

Emotion suppression reduces hippocampal activity during successful memory encoding.

Julia Binder1, Dominique J-F de Quervain, Malte Friese

  • 1Division of Biopsychology, University of Zurich, Switzerland. julia.binder@psychologie.uzh.ch

Neuroimage
|July 17, 2012
PubMed
Summary
This summary is machine-generated.

Emotion suppression impairs memory recall by reducing activity in the right hippocampus. This neural mechanism, involving reduced hippocampal-prefrontal connectivity, impacts memory encoding during emotional events.

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Related Experiment Videos

Last Updated: May 20, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
08:42

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition
16:08

Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

Published on: February 1, 2012

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Memory Research

Background:

  • Emotion suppression is known to impair memory recall.
  • The precise neural mechanisms behind this memory impairment are not fully understood.
  • Successful memory encoding typically involves the hippocampus and amygdala.

Purpose of the Study:

  • To investigate the neural mechanisms underlying memory impairment caused by emotion suppression.
  • To test the hypothesis that emotion suppression down-regulates activity in the hippocampus and amygdala.
  • To examine the relationship between brain activity, functional connectivity, and memory recall.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to record brain activity in 59 healthy females.
  • Participants were instructed to either passively view images or actively suppress their emotions using a response-focused strategy.
  • Free recall of images was assessed after the fMRI scan.

Main Results:

  • Emotion suppression led to significantly impaired recall of images compared to passive viewing.
  • Reduced activity was observed in the right hippocampus during successful memory encoding in the suppression group.
  • Emotion suppression decreased functional connectivity between the hippocampus and the right dorsolateral prefrontal cortex, predicting recall performance.

Conclusions:

  • Emotion suppression interferes with memory encoding at the hippocampal level.
  • The findings suggest that emotion suppression may impair memory by decoupling hippocampal and prefrontal encoding processes.
  • Response-focused emotion suppression could be an adaptive strategy to hinder hippocampal memory formation in highly arousing situations.