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Related Experiment Videos

Plasma versus bone marrow desipramine: a comparative study.

C L Winek1, S E Westwood, W W Wahba

  • 1Allegheny County Department of Laboratories, Pittsburgh, PA 15219.

Forensic Science International
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study found a direct correlation between bone marrow and plasma desipramine levels in rabbits. Bone marrow desipramine concentration increases with blood levels, suggesting its potential as an alternative sample site.

Area of Science:

  • Pharmacology
  • Toxicology
  • Biochemistry

Background:

  • Tricyclic antidepressants (TCAs) are widely prescribed.
  • The distribution of TCAs in different body tissues, particularly bone marrow, is not well understood.
  • Understanding tissue distribution is crucial for pharmacokinetic and toxicological assessments.

Purpose of the Study:

  • To investigate the correlation between plasma and bone marrow concentrations of desipramine, a commonly used TCA.
  • To determine if bone marrow can serve as an alternative biological matrix for desipramine analysis.

Main Methods:

  • Two groups of rabbits received oral desipramine (10 mg/kg or 20 mg/kg) daily for five days.
  • Blood and bone marrow samples were collected on day five post-administration.

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  • Desipramine concentrations were quantified using high-performance liquid chromatography (HPLC).

    • Main Results:

    • A significant positive correlation was observed between plasma and bone marrow desipramine levels.
    • Bone marrow desipramine concentration increased proportionally with increasing plasma concentrations.
    • The average ratio of bone marrow to plasma desipramine was 37.2 +/- 4.46, with a range of 30.99-44.82.

    Conclusions:

    • Bone marrow represents a viable alternative matrix for desipramine analysis when plasma samples are unavailable.
    • This finding has implications for therapeutic drug monitoring and toxicological investigations involving TCAs.
    • Further research should explore this correlation in humans and with other TCAs.