Related Experiment Video
Updated: May 20, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
N'-(3-Fluoro-benzyl-idene)-2-methyl-benzohydrazide
This study details the crystal structure of a fluorinated organic compound, C(15)H(13)FN(2)O. It reveals two distinct molecular conformations and highlights N-H⋯O hydrogen bonds forming crystal chains.
Area of Science:
- Crystallography
- Organic Chemistry
- Materials Science
Background:
- Understanding molecular conformation is crucial in chemistry.
- Crystal packing influences material properties.
- Hydrogen bonding plays a key role in molecular self-assembly.
Purpose of the Study:
- To characterize the crystal structure of the title compound C(15)H(13)FN(2)O.
- To analyze the conformational differences between independent molecules.
- To investigate the intermolecular interactions within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Conformational analysis focused on the dihedral angles of aromatic rings.
- Hydrogen bonding networks were identified and analyzed.
Main Results:
- The asymmetric unit contains two independent molecules of C(15)H(13)FN(2)O with differing conformations.
- Dihedral angles between aromatic rings were measured as 85.3(2)° and 10.0(2)° for the independent molecules.
- N-H⋯O hydrogen bonds were observed, linking molecules into chains along the [100] direction.
Conclusions:
- The crystal structure of C(15)H(13)FN(2)O exhibits conformational polymorphism.
- Intermolecular hydrogen bonding dictates the crystal packing arrangement.
- This structural information is vital for understanding the compound's physical and chemical properties.
More Related Videos
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Nucleophilic Aromatic Substitution: Elimination–Addition
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Diazonium Group Substitution: –OH and –H
Reactions at the Benzylic Position: Halogenation
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo, or cyano...

