Correlation of CT perfusion images with VEGF expression in solitary brain metastases
Jian-Hua Zhang1, Ming-Sheng Wang, Hai-Hong Pan
1Department of Radiology, East Hospital, Tongji University School of Medicine, Shanghai, China.
Objectives:
To obtain permeability surface (PS) values using multi-slice helical CT perfusion imaging and to evaluate the spatial distribution correlation between PS values and vascular endothelial growth factor (VEGF) expression in solitary brain metastases.
Methods:
Imaging was performed on 21 patients, PS values being calculated from the central, border and peripheral parts of tumours. VEGF expression was determined by immunohistochemical staining.
Results:
Rim enhancement was found in 16 cases, the border of the tumour featuring PS elevation with high VEGF expression in 13 cases. In the 5 cases with nodular enhancement, the border and the central part had high permeability and VEGF expression was high in all cases, the correlation being significant (P<0.01) .
Conclusion:
VEGF expression in brain metastases positively correlates with PS values from CT perfusion imaging, so that the latter can be used in the surveillance of angiogenic activity in brain metastases.
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