Related Experiment Video
Updated: May 20, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Vertically oval corneas in a child with holoprosencephaly
Esther S Lee1, Barry N Wasserman, Judy G Saslow
1Thomas Jefferson Medical College, Philadelphia, PA, USA.
Journal of Pediatric Ophthalmology and Strabismus
|July 18, 2012
Summary
Vertically oval corneas, a rare condition, were observed in a male infant. This case links this unusual corneal shape to semilobar holoprosencephaly.
Area of Science:
- Ophthalmology
- Medical Genetics
- Developmental Biology
Background:
- The typical human cornea is oval, with a greater horizontal than vertical diameter.
- Vertically oval corneas represent an uncommon deviation from normal corneal morphology.
- The underlying causes of vertically oriented oval corneas remain largely unknown.
Observation:
- A case study involving a male infant presented with bilateral vertically oval corneas.
- The infant was also diagnosed with semilobar holoprosencephaly, a congenital brain malformation.
Findings:
- This report documents the co-occurrence of vertically oval corneas and semilobar holoprosencephaly.
- The findings suggest a potential association between this specific corneal shape and holoprosencephaly.
Implications:
- This case may offer insights into the etiology of vertically oval corneas.
- Further research could explore potential genetic or developmental links between corneal shape and brain development anomalies.
- Understanding such associations can aid in early diagnosis and management of related conditions.
Related Concept Videos
01:27Cranial Bones: Lateral View
The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...
01:24Prosopagnosia
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
01:20Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
01:16Focusing of Light in the Eye
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...