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Updated: May 20, 2026
08:03
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Craniomaxillofacial features in hereditary multiple exostosis
Laura Pacheco Ruiz1, Jorge Chaurand Lara
1Department of Maxillofacial Surgery, National Medical Center 20 de Noviembre ISSSTE, Delegación Benito Juarez, México City, México.
The Journal of Craniofacial Surgery
|July 18, 2012
Summary
Hereditary multiple exostosis (HME) is a common bone dysplasia. This report details the first clinical case of bilateral coronoid osteochondroma and occipital exostosis in a patient with HME.
Area of Science:
- Orthopedics
- Genetics
- Oncology
Background:
- Hereditary multiple exostosis (HME) is an autosomal dominant bone dysplasia characterized by multiple osteochondromas.
- Osteochondromas are the most common benign bone tumors, typically affecting long bones.
Observation:
- Osteochondromas are rare in the craniofacial region, particularly the mandibular coronoid process (Jacob disease) and occipital bone.
- This study presents the first clinical report of bilateral coronoid osteochondroma and associated occipital exostosis in a patient diagnosed with HME.
Findings:
- The case highlights the unusual presentation of HME with craniofacial and skull base involvement.
- Bilateral coronoid osteochondroma and occipital exostosis were observed in the patient.
Implications:
- This case expands the known spectrum of HME manifestations.
- It underscores the importance of considering HME in patients with rare craniofacial bone tumors.
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