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Cell recognition and pattern formation in the developing nervous system.

D Trisler1

  • 1Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892.

The Journal of Experimental Biology
|October 1, 1990
PubMed
Summary

Cell position maps in the avian retina are inverted in the optic tectum. Orthogonal molecular gradients, TOP(DV) and TOP(AP), in the retina and tectum may form a coordinate system for retinotectal mapping.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Topographic maps in the avian visual system are crucial for processing visual information.
  • The precise mapping of retinal ganglion neurons to the optic tectum is essential for visual function.
  • Molecular gradients are hypothesized to guide the formation of these topographic maps.

Purpose of the Study:

  • To investigate the molecular mechanisms underlying the establishment of retinotectal topographic maps in avian species.
  • To identify specific molecules involved in specifying positional information in the retina and optic tectum.
  • To elucidate how inverted topographic mapping is achieved during neural development.

Main Methods:

  • Analysis of cell surface protein distribution in the avian retina and optic tectum.

Related Experiment Videos

  • Investigating the role of TOP(DV) and TOP(AP) proteins in establishing positional gradients.
  • Examining the relationship between retinal and tectal molecular gradients.

    • Main Results:

    • Cell position mapping in the avian retina is conserved but inverted in the optic tectum.
    • Two cell surface proteins, TOP(DV) and TOP(AP), exhibit distinct dorsoventral and anteroposterior gradients in the retina.
    • The optic tectum displays inverted gradients of these TOP molecules relative to the retina.

    Conclusions:

    • Orthogonal gradients of TOP(DV) and TOP(AP) molecules in the retina and optic tectum provide a potential Cartesian coordinate system.
    • These molecular gradients are key to specifying cell position and establishing the retinotectal map.
    • The findings offer insights into developmental mechanisms of neural pattern formation and topographic mapping.