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Updated: May 20, 2026

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology
Published on: August 18, 2014
Catecholamines, α-, and β-adrenoceptors are not responsible for activation of duodenum motility induced by
D S Sveshnikov1, V M Smirnov, I L Myasnikov
1Department of Physiology, N. I. Pirogov Russian State Medical University, Moscow, Russia.
Abstract:
Stimulation of sympathetic nerve in anesthetized dogs not treated with adrenergic blockers more frequently exerted stimulating rather than inhibitory effect on duodenal motility. Blockade of α- and β-adrenoceptors with phentolamine and propranolol, respectively, did not prevent the excitatory action of the sympathetic nerve stimulation, but even potentiated this effect. The data showed that catecholamines as well as α- and β-adrenoceptors are not involved in the excitatory effect of sympathetic origin.
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