Related Experiment Video
Updated: May 20, 2026

Dissection and Coronal Slice Preparation of Developing Mouse Pituitary Gland
Published on: November 16, 2017
Structural characteristics of adenohypophysis in hypertensive ISIAH rats in early ontogeny
I I Buzueva1, E E Filyushina, M D Shmerling
1Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. ibuzueva@physiol.ru
Abstract:
Comparative morphological study of the adenohypophysis was conducted in 3-week-old normotensive WAG and hypertensive ISIAH rats (prehypertension period) to elucidate the role of the adenohypophysis in the development of essential hypertension. Morphometric analysis revealed ultrastructural signs of functional activation of somatotrophs, gonadotrophs, and corticotrophs in ISIAH rats. These peculiarities of structural organization of adenohypophysis in hypertensive rats can attest to enhanced response of the hypothalamic-pituitary-adrenal axis in these animals to natural stress associated with their transition to independent feeding. Increased stress sensitivity during the prehypertensive period of postnatal ontogeny contributes to the development of arterial hypertension.
Related Concept Videos
The Pituitary Gland
Hypertension II: Pathophysiology
Cellular Adaptation II: Hypertrophy
