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Identification of a new HLA-DRB1 *16 variant, DRB1*16:19 by sequence-based typing in a Chinese Han

Z Li1, S-Z Jin, H-Y Zou

  • 1Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Guangdong Province, Shenzhen, China. sontony@yahoo.cn

Tissue Antigens
|July 19, 2012
PubMed

Abstract:

The sequence of the novel allele is identical to HLA-DRB1*16:02:01 except for one nucleotide change at nt203 (G→A), resulting in a coding change, 39 R (CGC)→H (CAC).

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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