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Updated: May 20, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Thermal dose fractionation affects tumour physiological response.

Donald E Thrall¹, Paolo Maccarini, Paul Stauffer

¹College of Veterinary Medicine, North Carolina State University, Raleigh, USA.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

|July 19, 2012

Summary

For canine sarcomas, administering one hyperthermia fraction weekly, rather than three to four, led to superior tumor volume reduction. This suggests a weekly hyperthermia schedule may be more effective.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

Oncology
Radiation Oncology
Biophysics

Background:

Determining optimal hyperthermia fractionation is crucial for cancer therapy.
The balance between fraction number and temperature for a given thermal dose remains unclear.

Purpose of the Study:

To compare the efficacy of one versus three to four weekly fractions of hyperthermia, delivering a total dose of approximately 30 CEM43T(90).
To assess the impact of different hyperthermia fractionation schedules on tumor response in canine sarcomas.

Main Methods:

Canine sarcomas were randomized to receive fractionated radiotherapy with either one or three to four weekly hyperthermia fractions.
Tumor response was evaluated using MRI (volume, oxygenation, diffusion), histology, and immunohistochemistry.

Main Results:

Tumors receiving one hyperthermia fraction per week showed greater reductions in volume and water diffusion.
Improved tumor oxygenation post-treatment correlated with volume reduction.
Changes in HIF-1α and CA-IX expression were observed, with an inverse relationship between temperature and CA-IX change.

Conclusions:

A hyperthermia schedule of one fraction per week was superior to three to four fractions per week.
The study did not identify advantages for more frequent hyperthermia administration.