The role of the brain's frontal eye fields in constructing frame of reference

Establishing contextual reference during discourse is a vital part of language function. Personal pronouns (e.g., he/she/it) are used to refer to previously experienced objects, utterances and events. These items, however, are often no longer present in the environment and have to be maintained and manipulated in working memory (WM). One aspect of this is the construction of a spatial frame of reference (e.g., "He was in front of it" where "he" is established as figure and "it" is the ground). The WM processes underlying this function may be different from those involved in establishing a non-spatial relation (e.g., "He was older than her"). The brain's frontal eye fields (FEFs), responsible for eye movement control, are known to be involved in processing spatial WM. This paper reviews both functional magnetic resonance imaging experiments and a subsequent behavioral interference study demonstrating a specific role for the FEFs and the brain's eye movement control system in manipulation of WM content for establishing object-centered spatial reference frames during verbally cued recall of recent visual and linguistic experiences.