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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Updated: May 20, 2026

A Macrophage-Tumor Spheroid Co-Invasion Assay

A Macrophage-Tumor Spheroid Co-Invasion Assay

Published on: January 24, 2025

New tricks for metastasis-associated macrophages.

Bin-Zhi Qian, Jeffrey W Pollard

Breast Cancer Research : BCR

|July 20, 2012

Summary

Metastasis-associated macrophages help breast cancer cells survive in the lungs. Targeting these immune cells and their signals offers a promising new therapeutic strategy for treating lung metastasis.

Area of Science:

Oncology
Immunology

Background:

Breast cancer lung metastasis involves complex interactions between tumor cells and the host immune microenvironment.
Metastasis-associated macrophages (MAMs) play a critical role in supporting tumor cell survival during metastatic processes.

Discussion:

This study elucidates a novel mechanism of tumor cell survival in lung metastasis mediated by signaling from metastasis-associated macrophages.
Understanding the specific signals provided by MAMs is crucial for developing targeted therapies.

Key Insights:

Identified a new mechanism of tumor cell survival in breast cancer lung metastasis.
Highlighted the critical role of metastasis-associated macrophages in supporting tumor cell survival.

Outlook:

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Targeting metastasis-associated macrophages and their signaling pathways presents a potential therapeutic avenue.
Further research into MAM-specific signals could lead to novel treatment strategies for advanced breast cancer.