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Updated: May 20, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
Interleukin 22-producing CD4+ T cells in malignant pleural effusion
Zhi-Jian Ye1, Qiong Zhou, Wen Yin
1Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China.
Increased T helper 22 (Th22) cells in malignant pleural effusion (MPE) promote cancer cell proliferation and adhesion. These findings reveal Th22 cells
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- T helper 22 (Th22) cells are implicated in human cancers.
- The role of Th22 cells in malignant pleural effusion (MPE) is not well understood.
Purpose of the Study:
- To investigate the differentiation and immune regulatory functions of Th22 cells in MPE.
- To explore the impact of Interleukin-22 (IL-22) on cancer cell behavior within the pleural environment.
Main Methods:
- Quantification of Th22 cell numbers in MPE samples.
- Assessment of IL-22's effects on A549 lung cancer cell proliferation, migration, and adhesion.
- Analysis of factors contributing to Th22 cell accumulation in MPE.
Main Results:
- Th22 cell counts were elevated in MPE.
- IL-22 significantly enhanced A549 cell proliferation and migration.
- IL-22 facilitated the adhesion of A549 cells to pleural mesothelial cells.
- Pleural cytokines and chemokines were identified as drivers for increased Th22 cells in MPE.
Conclusions:
- Th22 cells are increased in the MPE microenvironment.
- IL-22 plays a crucial role in promoting cancer cell progression and spread within the pleura.
- Th22 cells exert significant immune regulation on cancer cells in the human pleural malignant environment.
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