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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 20, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Brain metastases.

Christine Lu-Emerson1, April F Eichler

  • 1Harvard Medical School/ Massachusetts General Hospital, Boston 02114, USA.

Continuum (Minneapolis, Minn.)
|July 20, 2012
PubMed
Summary
This summary is machine-generated.

Brain metastases, common in advanced cancer, require multidisciplinary care. Treatment varies from whole-brain radiation therapy to surgery or stereotactic radiosurgery, focusing on patient status and tumor burden.

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Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
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Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

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Related Experiment Videos

Last Updated: May 20, 2026

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
07:43

Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection
07:42

Modelling Brain Metastasis: Standardized Analysis of Metastatic Colonization and Histological Growth Patterns by Stereotactic Intracortical Injection

Published on: January 16, 2026

Area of Science:

  • Neurology
  • Oncology
  • Radiotherapy

Background:

  • Brain metastases are the most frequent neurologic complication of systemic cancer.
  • Their incidence is rising due to improved systemic cancer treatments.
  • They pose a significant management challenge in advanced cancer care.

Purpose of the Study:

  • To review the clinical presentation of brain metastases.
  • To discuss the pathophysiology of metastatic brain tumors.
  • To outline prognostic factors and current treatment strategies.

Main Methods:

  • Review of existing literature on brain metastases.
  • Analysis of clinical presentation and symptoms.
  • Evaluation of treatment modalities and outcomes.

Main Results:

  • Brain metastases are 10x more common than primary brain tumors.
  • Symptoms include headache, weakness, altered mental status, and seizures.
  • Treatment choice depends on patient factors and tumor burden, with WBRT, surgery, and SRS as options.

Conclusions:

  • Multidisciplinary care is essential for optimizing outcomes in brain metastases.
  • Treatment strategies are tailored to individual patient profiles and disease extent.
  • Future research should incorporate quality of life and functional outcomes.